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Methadone 10mg
Methadone 10mg

Methadone 10mg is a medication used to relieve severe pain.It’s also used to prevent withdrawal symptoms in people who are addicted to opiate drugs such as morphine, hydrocodone, oxycodone, and fentanyl.

Methadone 10mg is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control.

Different forms

Tablet

1 mg
Each blue, round, flat-faced, bevelled-edged tablet, scored and embossed “1” on one side, with the Paladin shield logo on the other side, contains 1 mg methadone hydrochloride USP. Nonmedicinal ingredients: FD&C Blue No. 1 Lake, lactose, magnesium stearate, meglumine and microcrystalline cellulose.

5 mg
Each peach, round, flat-faced, bevelled-edged tablet, scored and embossed “5” on one side with the Paladin shield logo on the other side, contains 5 mg methadone hydrochloride, USP. Nonmedicinal ingredients: FD&C Yellow No. 6 Lake, lactose, magnesium stearate, meglumine and microcrystalline cellulose.

10 mg
Each pale green, round, flat-faced, bevelled-edged tablet, scored and embossed “10” on one side with the Paladin shield logo on the other side, contains 10 mg methadone hydrochloride USP. Nonmedicinal ingredients: D&C Yellow No. 10 Aluminium Lake, FD&C Blue No. 1 Lake, lactose, magnesium stearate, meglumine and microcrystalline cellulose.

25 mg
Each white-to-off-white, biconvex, caplet-shaped tablet, scored and embossed “25” on one side with the Paladin shield logo on the other side, contains 25 mg methadone hydrochloride USP. Nonmedicinal ingredients: lactose, magnesium stearate, meglumine and microcrystalline cellulose.

Oral Solution 1 mg/mL
Each 1 mL of clear unflavored and colorless liquid contains 1 mg of methadone hydrochloride USP. Nonmedicinal ingredients: citric acid (added to adjust the pH), dextrose, glycerin, methylparaben, polyethylene glycol, sodium benzoate, sodium cyclamate and water.

Oral Concentrate 10 mg/mL
Each 1 mL of clear unflavored and colorless liquid contains 10 mg of methadone hydrochloride USP. Nonmedicinal ingredients: citric acid (added to adjust the pH), dextrose, glycerin, propylene glycol, sodium benzoate, sodium cyclamate and water.

How to use

The initial dose of oral methadone in patients who require continuous pain control throughout the day can range from 2.5 to 10 mg given every 8 to 12 hours.
Those who are seriously ill may need to be started at an oral dose of 10 to 40 mg given every 6 to 12 hours.
The initial total daily dose for detoxification usually is higher, and this can range from 20 to 120 mg daily.
The usual dose for methadone solution for injection when treating moderate to severe pain in patients who require continuous pain control is 2.5 to 10 mg given as intravenous (I.V.), subcutaneous (SubQ) or intramuscular (I.M.) injection every 8-12 hours.
The conversion ratio from oral methadone to methadone given as an injection (I.V., SubQ) or I.M.) is 2:1. The total daily amount of methadone that a person is prescribed is not fixed, and it will depend on many factors including the severity of the pain, prior use of methadone, medications that are being taken concomitantly, the response to treatment and other factors that may be specific to a person.
Therefore, each person has to be monitored carefully while receiving methadone. When stopping therapy, the dose of methadone should be gradually reduced in order to avoid withdrawal symptoms.

Side effects

Methadone is very addicting and causes significant sedation and respiratory depression. Methadone side effects include:

constipation,
tomach upset,
nausea,
shallow breathing,
hallucinations,
confusion,
chest pain,
dizziness,
drowsiness,
fainting,
fast or pounding heartbeat,
trouble breathing,
feeling light-headed,
fainting, and
flushing
These tend to occur during the first few days as the body adjusts to the medication. Methadone also may cause:

irregular heartbeat,
anxiety,
tremors,
seizures,
rash and
itching.
Some of these side effects may go away with continued use.

Interactions

Methadone when taken with drugs that slow brain function, such as alcohol and barbiturates (phenobarbital), can increase the effects of these drugs.

Because methadone causes constipation, taking antidiarrheal medications such as diphenoxylate (Lomotil) and loperamide (Imodium) along with methadone can result in severe constipation.

Drugs that block narcotic (opioid) receptors including pentazocine (Talwin), nalbuphine (Nubain), naloxone (Narcan), butorphanol (Stadol) and buprenorphine (Subutex) can lead to withdrawal symptoms.

Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), phenytoin (Dilantin), primidone and St. John’s wort preparations can increase the liver’s ability to metabolize (eliminate) methadone and reduce its blood concentration which could result in withdrawal side effects, while drugs such as erythromycin (E-Mycin, Eryc, Ery-Tab), clarithromycin (Biaxin, Biaxin XL), ketoconazole (Nizoral), and itraconazole (Sporanox) can decrease the liver’s ability to metabolize methadone thereby increasing the side effects of this drug.
Anti-retroviral agents including abacavir (Ziagen), amprenavir (Agenerase), efavirenz (Sustiva), nelfinavir (Viracept), Nevirapine (Viramune, Viramune XR), Ritonavir (Norvir), and lopinavir/ ritonavir (Kaletra) have been shown to decreased the blood levels of methadone making it necessary to adjust the dose of methadone to prevent narcotic withdrawal effects.

Some drugs that slow the heart rate for example, dofetilide (Tikosyn), procainamide (Pronestyl, Procan-SR), quinidine, and sotalol (Betapace), as well as laxatives and diuretics that cause low magnesium or low potassium in the body, for example, furosemide (Lasix), can cause rare serious and fatal irregular heartbeats.

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